Dr. Brady Carter, METER’s Director of Food Science, discusses how to use water activity in pharmaceutical products to control pill stability and extend shelf life.
Topics covered include:
- How to assess the stability of a pill
- Basics of water activity
- Moisture content vs. water activity
- How to measure water activity
- Moisture sorption isotherms and how to use them
- Preventing microbial growth
- Preventing API degradation
- Gel coating integrity
- Moisture migration in capsules
- Determining relative hygroscopicity
- Water activity and glass transition
- Determining deliquescence point
- Excipients
- Storage humidity
- Packaging for extended shelf life
- An accelerated stability testing procedure